Support diagnostic workups for ankylosing spondylitis, reactive arthritis, and related rheumatologic presentations.
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RheumatologyImmunogenetics3 lab records3 source documents
HLA-B27 Association Testing
HLA-B27 association testing helps support evaluation of spondyloarthropathies when interpreted alongside clinical findings.
Synonyms: HLA-B27, HLA B27, Ankylosing spondylitis HLA-B27
Associated codes
Assay-level codes are separated from lab-specific codes. ICD-10 associations are informational only.
CPT
Not listed by source
ICD10
Not listed by source
LOINC
26028-1
HLA-B27, Blood
Order/result LOINC listed by Mayo.
OTHER
Not listed by source
Cross-lab comparison
A concise side-by-side view of ordering and handling differences across current source-backed records.
| Field | Labcorp Labcorp HLA B 27 Disease Association | Mayo Clinic Laboratories Mayo HLA-B27, Blood | Quest Diagnostics Quest HLA-B27 Antigen |
|---|---|---|---|
| Category | standard | standard | standard |
| Test name | HLA B 27 Disease Association | HLA-B27, Blood | HLA-B27 Antigen |
| Codes | Test 006924, Order 006924 | LOINC 26028-1 | Test 528, Order 528 |
| Specimen | Whole blood | Whole blood EDTA | Not listed by source |
| Container | Lavender-top (EDTA) tube | Lavender top (EDTA) | Not listed by source |
| Handling | Not listed by source | Send whole blood specimen in original tube. Do not aliquot. | Not listed by source |
| Storage | Maintain blood specimen at room temperature. | Ambient | Not listed by source |
| Turnaround time | 3 - 7 days | Not listed by source | Not listed by source |
| Methodology | Polymerase chain reaction (PCR) / sequence-specific oligonucleotide probes (SSOP) | Flow cytometry | Not listed by source |
| Source-listed price | Not listed by source | Not listed by source | Not listed by source |
| Reflex logic | Not listed by source | Not listed by source | Not listed by source |
| Limitations | A positive result supports but does not establish a diagnosis of ankylosing spondylitis or related disorders. | HLA-B27 is associated with several rheumatic diseases but is not diagnostic in isolation. | Public source is a test menu PDF and does not expose full specimen handling details. |
| Source coverage | Labcorp: 1 source | Mayo: 1 source | Quest: 1 source |
Labcorp
Labcorp HLA B 27 Disease Association
- Category
- standard
- Test name
- HLA B 27 Disease Association
- Codes
- Test 006924, Order 006924
- Specimen
- Whole blood
- Container
- Lavender-top (EDTA) tube
- Handling
- Not listed by source
- Storage
- Maintain blood specimen at room temperature.
- Turnaround time
- 3 - 7 days
- Methodology
- Polymerase chain reaction (PCR) / sequence-specific oligonucleotide probes (SSOP)
- Source-listed price
- Not listed by source
- Reflex logic
- Not listed by source
- Limitations
- A positive result supports but does not establish a diagnosis of ankylosing spondylitis or related disorders.
- Source coverage
- Labcorp: 1 source
Mayo
Mayo HLA-B27, Blood
- Category
- standard
- Test name
- HLA-B27, Blood
- Codes
- LOINC 26028-1
- Specimen
- Whole blood EDTA
- Container
- Lavender top (EDTA)
- Handling
- Send whole blood specimen in original tube. Do not aliquot.
- Storage
- Ambient
- Turnaround time
- Not listed by source
- Methodology
- Flow cytometry
- Source-listed price
- Not listed by source
- Reflex logic
- Not listed by source
- Limitations
- HLA-B27 is associated with several rheumatic diseases but is not diagnostic in isolation.
- Source coverage
- Mayo: 1 source
Quest
Quest HLA-B27 Antigen
- Category
- standard
- Test name
- HLA-B27 Antigen
- Codes
- Test 528, Order 528
- Specimen
- Not listed by source
- Container
- Not listed by source
- Handling
- Not listed by source
- Storage
- Not listed by source
- Turnaround time
- Not listed by source
- Methodology
- Not listed by source
- Source-listed price
- Not listed by source
- Reflex logic
- Not listed by source
- Limitations
- Public source is a test menu PDF and does not expose full specimen handling details.
- Source coverage
- Quest: 1 source
Detailed lab records
Each card preserves lab-specific terminology, operational notes, and direct source links.
Labcorpstandard
Labcorp HLA B 27 Disease Association
HLA B 27 Disease Association
Test 006924, Order 006924
Aliases
HLA-B27 Disease Association, HLA B 27 Disease Association
Test code
006924
Order code
006924
Test ID
Not listed by source
Specimen type
Whole blood
Preferred volume
Adult tube
Minimum volume
0.5 mL
Container
Lavender-top (EDTA) tube
Handling
Not listed by source
Storage
Maintain blood specimen at room temperature.
Transport temperature
Room temperature
Stability
Not listed by source
Turnaround time
3 - 7 days
Methodology
Polymerase chain reaction (PCR) / sequence-specific oligonucleotide probes (SSOP)
Use / clinical significance
Evaluate spondyloarthritis and other disorders associated with HLA-B27.
Patient preparation
Not listed by source
Collection instructions
Not listed by source
Rejection criteria
Hemolysis; clotted specimen; tube other than lavender-top (EDTA) tube
Includes
Not listed by source
Reflex logic
Not listed by source
Limitations
A positive result supports but does not establish a diagnosis of ankylosing spondylitis or related disorders.
Interferences
Adequate testing requires intact lymphocytes at the time of testing.
Performing schedule
Not listed by source
Notes
Labcorp describes this as a class I antigen level test.
Source-listed price
Not listed by source
Informational ICD-10
Not listed by source
Source links
- Labcorp HLA-B27 disease association(test-page)
Primary source for methodology, storage, turnaround time, and use.
Mayo Clinic Laboratoriesstandard
Mayo HLA-B27, Blood
HLA-B27, Blood
ID LY27B, LOINC 26028-1
Aliases
LY27B
Test code
Not listed by source
Order code
Not listed by source
Test ID
LY27B
Specimen type
Whole blood EDTA
Preferred volume
6 mL
Minimum volume
1 mL
Container
Lavender top (EDTA)
Handling
Send whole blood specimen in original tube. Do not aliquot.
Storage
Ambient
Transport temperature
Ambient
Stability
4 days
Turnaround time
Not listed by source
Methodology
Flow cytometry
Use / clinical significance
Assists in the diagnostic process of ankylosing spondylitis, juvenile rheumatoid arthritis, and reactive arthritis.
Patient preparation
Not listed by source
Collection instructions
Send whole blood specimen in original tube.
Rejection criteria
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Includes
Interpretive report
Reflex logic
Not listed by source
Limitations
HLA-B27 is associated with several rheumatic diseases but is not diagnostic in isolation.
Interferences
Extreme temperature changes during shipping may alter specimen acceptability.
Performing schedule
Not listed by source
Notes
Useful-for and LOINC metadata sourced from Mayo Test Catalog overview.
Source-listed price
Not listed by source
Informational ICD-10
Not listed by source
Source links
- Mayo HLA-B27 overview(test-page)
Primary source for specimen requirements, methodology, and LOINC.
Quest Diagnosticsstandard
Quest HLA-B27 Antigen
HLA-B27 Antigen
Test 528, Order 528
Aliases
HLA-B27 antigen
Test code
528
Order code
528
Test ID
Not listed by source
Specimen type
Not listed by source
Preferred volume
Not listed by source
Minimum volume
Not listed by source
Container
Not listed by source
Handling
Not listed by source
Storage
Not listed by source
Transport temperature
Not listed by source
Stability
Not listed by source
Turnaround time
Not listed by source
Methodology
Not listed by source
Use / clinical significance
Quest lists HLA-B27 Antigen under ankylosing spondylitis in its autoimmune testing menu.
Patient preparation
Not listed by source
Collection instructions
Not listed by source
Rejection criteria
Not listed by source
Includes
Not listed by source
Reflex logic
Not listed by source
Limitations
Public source is a test menu PDF and does not expose full specimen handling details.
Interferences
Not listed by source
Performing schedule
Not listed by source
Notes
Quest also lists a separate HLA-B27 DNA typing option (test code 15584) in the same source menu.
Source-listed price
Not listed by source
Informational ICD-10
Not listed by source
Source links
- Quest autoimmune testing menu PDF(pdf)
Menu lists HLA-B27 Antigen test code 528.
Supporting references
test-page1 linked record(s)
Labcorp HLA-B27 disease association
https://www.labcorp.com/tests/006924/hla-b-27-disease-associationMethodology, specimen requirements, turnaround time, and use.
test-page1 linked record(s)
Mayo HLA-B27 overview
https://www.mayocliniclabs.com/test-catalog/overview/9648Specimen requirements, useful-for text, and LOINC.
pdf2 linked record(s)
Quest autoimmune testing menu PDF
https://www.questdiagnostics.com/content/dam/corporate/restricted/documents/hcp/q1-sprint--ana/lab-director/TL12703_10599-SprintTestMenu_2-12-24_v4.pdfQuest PDF menu used for provider test codes.
Disclaimer
AssayIndex is an informational reference workspace. Verify current requirements, ordering details, and billing guidance with the source laboratory before ordering or submitting claims.